Welcome to the Elizondo Lab!

The Elizondo Lab investigates how immune dysfunction contributes to the breakdown of tissue integrity and glucose homeostasis in diabetes. Using transgenic mouse models of autoimmune (non-obese diabetic) and obesity-induced diabetes, we explore the molecular pathways that drive chronic inflammation, insulin resistance, and metabolic failure.

We apply a wide range of advanced techniques, including: I) Flow cytometry and immune cell profiling; II) RNA interference and CRISPR-based gene editing; III) Single-cell and bulk RNA sequencing IV) Glucose/insulin tolerance testing and metabolic phenotyping; V) qPCR; VI) ELISA;  VII) western blotting; VIII) IX) multiplex cytokine analysis; X) Primary cell culture (adipocytes, macrophages, T cells, pancreatic islets); XI Fluorescence microscopy; and XII) In vivo lentiviral delivery and transgenic mouse models

We welcome motivated undergraduate and graduate students to join our collaborative and dynamic research team. If you’re interested in learning more, please reach out to us at elizondolaboratory@gmail.com.